Phone: (509)-313-5933 Fax: (509)-313-5804 eMail: Office#: HU 240
I am interested in genes, chromosomes, and genomes: how they contribute to the traits of an organism, how they are transmitted during cell division, and how they can change from generation to generation. My research makes use of the brewer's yeast Saccharomyces cerevisiae as a model eukaryotic organism. My students and I are working to understand how a common mistake in cell division--resulting in an extra chromosome--affects phenotype, genome stability, and ultimately, fitness. We use a variety of methods, including recombinant DNA techniques, microbial genetics, and whole-genome microarrays. I encourage any student who is interested in participating in molecular genetic research to contact me to discuss possibilities for getting involved. Students (even non-biologists) who want to apply computer science skills to genomics and bioinformatics are also welcome. See my lab web site for more information.
Education
Ph.D., Genetics, University of Wisconsin, Madison, Wisconsin, 1997.
Associate Professor, Department of Biology, Gonzaga University, 2009-present.
Assistant Professor, Department of Biology, Gonzaga University, 2003-2009.
Postdoctoral Fellow, Department of Genetics, Stanford University School of Medicine, 1997-2003.
Visiting Instructor, Department of Biology, Hendrix College, 1996-1997.
Research Technician, Laboratory of Experimental Pathology, Fred Hutchinson Cancer Research Center, Seattle, WA, 1987-1989.
Teaching
Cellular Biology, BIOL 201
Genetics and Evolution, BIOL 202
Advanced Genetics: Genomics, BIOL 335
Developmental Biology, BIOL 337
Advanced Topics, BIOL 399
Molecular Biology, BIOL 456
Senior Colloquium, BIOL 499
Publications (undergraduate students are underlined)
Anders, K. R., Kudrna, J. R.,
Keller, K. E., Kinghorn, B.., Miller, E. M., Pauw, D., Peck, A. T., Shellooe, C. E., Strong, I. J. T. (2009) A
strategy for constructing aneuploid yeast strains by transient
nondisjunction of a target chromosome. BMC Genetics 10:36.
Anders, K. R.*, Grimson, A.*, Anderson, P. (2003) smg-5 is required for mRNA surveillance in Caenorhabditis elegans and encodes a novel component of protein phosphatase 2A. EMBO J 22:641-650. (* denotes equal contribution)
Ohnishi, T., Yamashita, A., Kashima, Schell, T., Anders, K. R., Grimson, A., Hachiya, T., Hentze, M. W., Anderson, P., Ohno, S. (2003) Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell 12:1187-1200.
Anders, K. R., and Botstein, D. (2001) Dominant-lethal alpha-tubulin mutants defective in microtubule depolymerization in yeast. Mol Biol Cell 12:3973-3986.
Richards, K. L.*, Anders, K. R.*, Nogales, E., Schwartz, K., Downing, K. H., Botstein, D. (2000) Structure-function relationships in yeast tubulins. Mol Biol Cell 11:1887-1903. (* denotes equal contribution)
Page, M. F., Carr, B., Anders, K. R., Grimson, A., and Anderson, P. (1999) SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol 19:5943-5951.
Spellman, P. T., Sherlock, G., Zhang, M. Q., Iyer, V. R., Anders, K., Eisen, M. B., Brown, P. O., Botstein, D., and Futcher, B. (1998) Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell 9:3273-3297.
Durnam, D. M., Anders, K. R., Fisher, L., O'Quigley, I., Bryant, I. M., and Thomas, E. D. (1989) Analysis of the origin of marrow cells in bone marrow transplant recipients using a Y chromosome-specific in situ hybridization assay. Blood 74:2220-2226.
Peters, M. G., Secrist, H., Anders, K. R., Nash, G. S., Rich, S. R., and MacDermott, R. P. (1989) Normal human intestinal B lymphocytes: increased activation compared with peripheral blood. J Clin Invest 83:1827-1833.
I am interested in genes, chromosomes, and genomes: how they contribute to the traits of an organism, how they are transmitted during cell division, and how they can change from generation to generation.